Rhabdomyolysis-Induced Acute Kidney Injury Under Hypoxia and Deprivation of Food and Water
| Autor: | Shaoxia Wang, Dewen Wang, Ya-bing Gao, Guo Xiaoming, Ruiyun Peng, Jingwen Wang, Shuiming Wang, Yang Li, Hong-yan Zuo, Xinping Xu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Renal lesion lcsh:Diseases of the circulatory (Cardiovascular) system Urology Apoptosis Hindlimb urologic and male genital diseases lcsh:RC870-923 Rhabdomyolysis chemistry.chemical_compound medicine lcsh:Dermatology Animals Rats Wistar Intensive care medicine Hypoxia Creatinine Water Deprivation business.industry Acute kidney injury General Medicine Hypoxia (medical) lcsh:RL1-803 medicine.disease lcsh:Diseases of the genitourinary system. Urology Rats chemistry Nephrology lcsh:RC666-701 Histopathology medicine.symptom Cardiology and Cardiovascular Medicine business Food Deprivation |
| Zdroj: | Kidney & Blood Pressure Research, Vol 37, Iss 4-5, Pp 414-421 (2013) |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Background: To investigate the renal pathophysiologyin rhabdomyolysis-induced acute kidney injury (AKI) in rats under hypoxia and deprivation of food and water (HDFW), thus broadening the knowledge about rhabdomyolysis-induced AKI in massive earthquake. Methods: Male Wistar rats weighing 200-230g were randomized into control, rhabdomyolysis (R), HDFW and rhabdomyolysis in combination with HDFW (R/HDFW) group. Experimental rhabdomyolysis rat model was established through clamping hind limb muscles, HDFW model rats were kept in 10% hypoxic chamber unavailable to food and water. At 1, 3, 5, 7, 9, 11d after treatment, serum creatinine (Scr) level, renal index, renal structural changes and cell apoptosis were analyzed. Results: After R, HDFW, R/HDFW treatment, the animals showed significantly higher Scr levels than the control group. Renal index in R and R/HDFW groups elevated remarkably compared with that in control and HDFW group. The results of histopathology, ultra-structure and apoptosis assay suggested that rhabdomyolysis caused renal tubular injury, HDFW treatment resulted in renal vascular dilation, tissue congestion and tubular cell damage. In addition, more severe renal lesion appeared in R/HDFW. Conclusions: We conclude that the association of experimental rhabdomyolysis with HDFW results in a different functional and histological pattern. The rhabdomyolysis-HDFW combination causes more severe renal injury. |
| Databáze: | OpenAIRE |
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