An improvement in acute wound healing in rats by the synergistic effect of photobiomodulation and arginine
| Autor: | Sufan Chien, Abdollah Amini, Ensieh Sajadi, Mohammad Bayat, Mohammad Bidram, Amirhossein Gomi Avili, Seyed Ali Karimifard, Seyed Kamran Ghoreishi, Mahsa Hadipour Jahromy, Atarodsadat Mostafavinia, Mohammadamin Mahmanzar |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Excisional wound Arginine Stereology Pharmacology Wound closure 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Medicine lcsh:QH301-705.5 lcsh:R5-920 Wound strength integumentary system business.industry Treatment regimen Research Acute wound healing Photobiomodulation 3. Good health 030104 developmental biology Wound area lcsh:Biology (General) Acute wound Rat Tensiometrical properties lcsh:Medicine (General) business Wound healing |
| Zdroj: | Laboratory Animal Research Laboratory Animal Research, Vol 35, Iss 1, Pp 1-11 (2019) |
| ISSN: | 2233-7660 1738-6055 |
| Popis: | In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess the impact of photobiomodulation (PBM) and arginine, individually and together, on the wound healing. In the pilot study, an excisional wound was made in each of 24 rats. There were 4 groups. Group 1 was the control group. In groups 2 and 3, wounds were topically treated with arginine ointments (ARG.) 2% and 5%, respectively. In group 4, arginine was injected (ARG. INJ.,i.p.). In the main phase, in 24 new rats, an excisional wound was made. There were 4 groups: group 5 served as the control. Wounds in group 6 were topically treated with ARG 2%. Wounds in group 7 were subjected to PBM. Wounds in group 8 were treated with PBM+ARG. 2%. On day 15, wound area measurement, wound strength, and stereological examination were performed. In the pilot study, we found that the ARG 2% ointment significantly decreased wound area than ARG. 5%, ARG. INJ. and control groups, and significantly increased wound strength compared to the control and ARG.5% groups. In the main phase, a significant decrease of wound area in all treatment regimens was induced. PBM + ARG. 2% and PBM treatment regimens significantly improved wound strength and almost all stereological parameters, compared to the control and ARG. 2% groups. PBM + ARG. 2% induced anti-inflammatory and angiogenic activities, and hastened the wound healing process in an excisional wound model in rats. |
| Databáze: | OpenAIRE |
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