D-dimer from central and peripheral blood samples in asymptomatic central venous catheter-related thrombosis in patients with cancer
| Autor: | José Carlos Jaime-Pérez, Gerardo E Ornelas-Cortinas, Tomas Nangullasmu-Plasencia, Linda Muñoz-Espinoza, Juan Francisco González-Guerrero, Carlos R Camara-Lemaroy, Moises Gonzalez-Escamilla, Osvaldo Chipuli-Lopez, Homero Náñez-Terreros, Ricardo D Ramos-Dena |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Catheters medicine.medical_treatment 030204 cardiovascular system & hematology 030230 surgery Gastroenterology Asymptomatic Fibrin Fibrinogen Degradation Products 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine D-dimer medicine Humans In patient Aged business.industry Cancer Thrombosis Ultrasonography Doppler General Medicine Venous blood Middle Aged medicine.disease Peripheral Female medicine.symptom Cardiology and Cardiovascular Medicine business Central venous catheter |
| Zdroj: | Phlebology: The Journal of Venous Disease. 34:52-57 |
| ISSN: | 1758-1125 0268-3555 |
| Popis: | Objectives To evaluate the usefulness of a negative D-dimer in peripheral or central venous blood to screen for asymptomatic catheter-related thrombosis in cancer patients. Methods D-dimer was measured in blood from central venous catheter and peripheral venous samples in 48 patients with cancer. Asymptomatic catheter-related thrombosis was identified via Doppler ultrasound. Bland and Altman’s limits of agreement analysis was used to compare sample sites. Sensitivity and specificity of D-dimer was calculated. Results Overall, 33 of the central samples and 32 of the peripheral samples had D-dimer levels below the cutoff (≥0.3 mg/l). Mean central D-dimer was 0.31 ± 0.35 mg/l; peripheral 0.24 ± 0.22 mg/l (p = 0.5). Bland–Altman plot showed that the two sample sites were not equivalent. Catheter-related thrombosis was demonstrated in five patients, and there were three false negatives. Peripheral D-dimer had a negative predictive value of 90.9%. Conclusions A negative D-dimer may be useful for screening asymptomatic catheter-related thrombosis in patients with cancer, but the central and peripheral sample sites are not equivalent. |
| Databáze: | OpenAIRE |
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