Neuromolecular Modulation of Experimentally-Induced Retrograde Amnesia
| Autor: | Essman Wb |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Cytoplasm
Serotonin Nerve Tissue Proteins Hippocampus Mice Norepinephrine Leucine medicine Animals Humans Electroconvulsive Shock Myelin Sheath Cerebral Cortex Nerve Endings Carbon Isotopes Electroshock Molecular interactions Age Factors Brain Retrograde amnesia medicine.disease Mitochondria Memory Short-Term RNA Surgery Amnesia Synaptic Vesicles Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Stereotactic and Functional Neurosurgery. 35:1-22 |
| ISSN: | 1423-0372 1011-6125 |
| DOI: | 10.1159/000102824 |
| Popis: | The effect of a single post-training electroconvulsive shock (ECS) treatment has been shown to effect (1) a retrograde amnesia for avoidance behavior in the mouse, (2) a change in the level and metabolism of brain 5-hydroxytryptamine (5-HT), and (3) an inhibition of regional protein synthesis. Injection of physiological quantities of 5-HT into the hippocampal region was effective incausing a retrograde amnesia and also inhibiting cerebral protein synthesis. This effect appeared specific to 5-HT, as other analogs or amines failed to exert a comparable behavioral effect. An age-dependent effect of the amnesia, 5-HT increment, and inhibition of the protein synthesis was demonstrated in that the 17 day old animal showed a marked resistence to the behavioral and biochemical effects of 5-HT. Several molecular interactions having possible significance for synaptic modulation of changes associated with experimentally induced retrograde amnesia have been considered. |
| Databáze: | OpenAIRE |
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