Dissecting the Kinetic Process of Amyloid Fiber Formation through Asymptotic Analysis
| Autor: | Liu Hong, Yang Zhang, Xianghong Qi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Amyloid Asymptotic analysis Chemistry Globular protein Amyloidosis medicine.disease Article Surfaces Coatings and Films Solutions Kinetics Crystallography Exponential growth Phase (matter) Master equation Materials Chemistry medicine Biophysics Fiber Physical and Theoretical Chemistry |
| Zdroj: | The Journal of Physical Chemistry B. 116:6611-6617 |
| ISSN: | 1520-5207 1520-6106 |
| DOI: | 10.1021/jp205702u |
| Popis: | Amyloids are insoluble fibrous protein aggregates which, when abnormally accumulated in the body, can result in amyloidosis and various neurodegenerative diseases. In this work, we describe a new approach to the asymptotic solution of the master equation of amyloid fiber aggregations. It is found that four distinct and successive stages (lag phase, exponential growth phase, breaking phase, and static phase) dominate the fiber formation process. On the basis of the distinctive power-law dependence of the half-time and apparent growth rate of the fiber formation on the initial protein concentration, we propose a novel classification for amyloid proteins theoretically. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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