Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing
| Autor: | Michael V. Morabito, Richard T. O’Neil, Xiaojing Wang, Ronald B. Emeson |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Adenosine Deaminase Discrete Brain Region Population 5HT2C Receptor RNA-binding protein Context (language use) Computational biology Brain tissue lcsh:RC346-429 Adenosine Deaminase Acting Neuronal signaling 03 medical and health sciences Cellular and Molecular Neuroscience Animals Humans GABRA3 education Molecular Biology lcsh:Neurology. Diseases of the nervous system Cerebral Cortex education.field_of_study Editing Efficiency Non human primate biology Research Brain RNA-Binding Proteins Macaca mulatta Neostriatum 030104 developmental biology nervous system RNA editing biology.protein Editing Site RNA Editing Neuroscience |
| Zdroj: | Molecular Brain, Vol 10, Iss 1, Pp 1-9 (2017) Molecular Brain |
| ISSN: | 1756-6606 |
| DOI: | 10.1186/s13041-017-0291-1 |
| Popis: | A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the relationships between the extent of editing at multiple substrate transcripts (5HT2C, MGLUR4, CADPS, GLUR2, GLUR4, and GABRA3) in brain tissue obtained from adult humans and rhesus macaques. Several patterns emerged from these studies revealing conservation of editing across primate species. Additionally, variability in the human population allows us to make novel inferences about the co-regulation of editing at different editing sites and even across different brain regions. Electronic supplementary material The online version of this article (doi:10.1186/s13041-017-0291-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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