Meningococcal carriage in adolescents in the United Kingdom to inform timing of an adolescent vaccination strategy
| Autor: | Kathrin U. Jansen, Nicholas Kitchin, Catherine A. Jeppesen, Tessa M. John, M Casey, Stuart C. Clarke, Paul T. Heath, Adam Finn, Ifeanyichukwu O Okike, Shamez N Ladhani, Nicoletta Gossger, Hal Jones, Matthew D. Snape, Joseph Eiden, Filipa Martins, Hannah Robinson, Pippa Taylor, Andrew J. Pollard, Saul N. Faust, Clarissa Oeser, Jennifer Oliver, Alison Kent, Annaliesa S. Anderson, Begonia Morales-Aza, Merryn Voysey, Louise Pedneault |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Microbiology (medical) Pediatrics medicine.medical_specialty Adolescent Population Neisseria meningitidis medicine.disease_cause Serogroup Adolescents Polymerase Chain Reaction Young Adult Bacterial Proteins Agglutination Tests medicine Humans Longitudinal Studies Young adult education Child education.field_of_study Antigens Bacterial Carriage business.industry Pharynx Vaccination Adolescent vaccination United Kingdom 3. Good health Meningococcal Infections Epidemiologic Studies medicine.anatomical_structure Infectious Diseases Meningococcal carriage Carrier State Factor H binding protein business |
| DOI: | 10.1016/j.jinf.2015.02.006 |
| Popis: | OBJECTIVES: Recent development of serogroup B meningococcal (MenB) vaccines highlights the importance of pharyngeal carriage data, particularly in adolescents and young adults, to inform implementation strategies. We describe current UK carriage prevalence in this high risk population and compare methods of carriage detection. METHODS: In this multisite study, pharyngeal swabs were collected on 3-4 occasions over 6-12 months, from 1040 school and university students, aged 10-25 years. Meningococcal carriage was detected by standard culture combined with seroagglutination or PCR of cultured isolates, or by direct PCR from swab. The factor H binding protein (fHBP) variants present in meningococcal isolates were determined. RESULTS: Meningococcal serogroups B and Y were most common, with carriage up to 6.5% and 5.5% respectively, increasing throughout adolescence. Identification by seroagglutination was often unreliable, and the sensitivity of direct PCR detection was 66% compared to culture combined with PCR. Of MenB isolates, 89.1% had subfamily A variants of fHBP. The acquisition rate of MenB carriage was estimated at 2.8 per 1000 person-months. CONCLUSIONS: If vaccination is to precede the adolescent rise in MenB carriage, these data suggest it should take place in early adolescence. Studies assessing vaccine impact should use molecular methods to detect carriage. |
| Databáze: | OpenAIRE |
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