Synthesis of a new organic probe 4-(4 acetamidophenylazo) pyrogallol for spectrophotometric determination of Bi(III) and Al(III) in pharmaceutical samples
| Autor: | Zainab A. Khan, Jumana W. Ammar, Naser A. Naser, Marwa N. Ghazi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
synthesis
Chemistry al(iii) 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences 010406 physical chemistry 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Pyrogallol p-aminoacetanilide 0210 nano-technology pharmaceutical applications pyrogallol QD1-999 bi(iii) Nuclear chemistry |
| Zdroj: | Reviews in Analytical Chemistry, Vol 40, Iss 1, Pp 108-126 (2021) |
| ISSN: | 2191-0189 |
| DOI: | 10.1515/revac-2021-0125 |
| Popis: | A modern development discusses the synthesis and validity of simple, sensitive, and versatile spectrophotometric methods for Bi(III) and Al(III) determination in pharmaceutical formulations have been conducted. In the present paper, 4-(4 acetamidophenylazo) pyrogallol has been synthesized as a new organic compound, 4-APAP, by coupling pyrogallol in a regulated pH medium with diazotized p-aminoacetanilide. 4-APAP was identified by methods of FT-IR, 1H-NMR, 13C-NMR, and thermal analysis (thermogravimetry and differential scanning calorimetry). Solvatochromic activity was also studied in solvents with different polarities. The Kamlet and Taft linear solvation energy relationship was used to correlate shifts in UV-Visible spectra of 4-APAP with Kamlet-Taft parameters (α, β, and π*). The optimum assay conditions showed linearity from 0.3–13 to 0.5–11 μg·mL−1 for Bi(III) and Al(III), respectively. Molar absorptivity values were 3.365 × 104 and 0.356 × 104 L·mol−1·cm−1 for Bi(III) and Al(III), with similar Sandell's sensitivity measures of 0.006 and 0.008 μg·cm−2. Detection limits and quantification limits were 0.013 and 0.043 μg·mL−1 for Bi(III), respectively, and 0.018 and 0.059 μg·mL−1 for Al(III) with the relative standard deviation for determination of both metal ions using 4-APAP probe being |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |