Bactericidal capacity of polymorphonuclear leukocytes from patients receiving theophylline therapy
| Autor: | Armand B. Glassman, Catherine U. Kyong, Bruce E Ponce, H. Hugh Fudenberg, Margaret E. Mohrmann |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adenosine monophosphate
Adult Blood Bactericidal Activity Staphylococcus aureus Adolescent Neutrophils Immunology Pharmacology medicine.disease_cause chemistry.chemical_compound Theophylline Immunology and Allergy Medicine Humans Child Colony-forming unit Polymorphonuclear leukocyte business.industry Significant difference Infant Middle Aged Asthma chemistry Child Preschool business medicine.drug |
| Zdroj: | The Journal of allergy and clinical immunology. 69(5) |
| ISSN: | 0091-6749 |
| Popis: | The capacity of polymorphonuclear leukocytes (PMNs) to kill Staphylococcus aureus strains 502 A was studied in 25 patients receiving theophylline therapy and in normal healthy controls. A significant difference in PMN bactericidal capacity was found between controls and patients with serum theophylline levels higher than 8 micrograms/ml, as determined by high-pressure liquid chromatography. The bactericidal capacity of PMNs from both the patient and control populations was reduced in the presence of theophylline levels above 8 micrograms/ml. In addition, a transient but significant drug-independent reduction was found in the bactericidal capacity of transient but significant drug-independent reduction was found in the bactericidal capacity of PMNs from patients receiving theophylline. |
| Databáze: | OpenAIRE |
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