Postprandial coagulation activation in overweight individuals after weight loss: Acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet
| Autor: | Else-Marie Bladbjerg, Arne Astrup, Steen Stender, Anette Pia Due, Jørgen Jespersen, Thomas Meinert Larsen |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Very low-density lipoprotein Overweight Fibrinogen Dietary Fats Unsaturated Weight loss Internal medicine Weight Loss medicine Humans Prospective Studies Blood Coagulation Diet Fat-Restricted Meal biology Chemistry C-reactive protein Feeding Behavior Hematology Postprandial Period Dietary Fats Postprandial Endocrinology Cardiovascular Diseases biology.protein Female medicine.symptom Body mass index medicine.drug |
| Zdroj: | Bladbjerg, E-M, Larsen, T M, Due, A P, Jespersen, J, Stender, S & Astrup, A 2014, ' Postprandial coagulation activation in overweight individuals after weight loss : Acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet ', Thrombosis Research, vol. 133, no. 3, pp. 327-333 . https://doi.org/10.1016/j.thromres.2013.12.010 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/j.thromres.2013.12.010 |
| Popis: | Diet is important in the prevention of cardiovascular disease, and it has been suggested that a high-MUFA diet is more cardioprotective than a low-fat diet. We hypothesised that the postprandial thrombotic risk profile is improved most favourably by a high-MUFA diet compared with a low-fat diet. This was tested in a parallel intervention trial on overweight individuals (aged 28.4 (SD 4.7) years) randomly assigned to a MUFA-diet (35-45% of energy as fat; >20% as MUFA, n = 21) or a low-fat (LF) diet (20-30% of energy as fat, n = 22) for 6 months after a weight loss of ~10%. All foods were provided free of charge from a purpose-built supermarket. Meal tests designed after the same principles were performed before and after the dietary intervention, and blood samples were collected at 8.00 h (fasting), 12.00 h, and 18.00 h and analysed for factor VII coagulant activity (FVII:C), activated FVII, fibrinogen, prothrombin fragment 1 + 2 (F1 + 2), D-dimer, plasminogen activator inhibitor (PAI:Ag), and thrombin activatable fibrinolysis inhibitor. There were significant postprandial increases in F1 + 2 and D-dimer before and after dietary intervention, with significantly lower values after 6 months. No significant differences were observed between the postprandial changes induced by the two diets. The postprandial decrease in FVII:C and PAI:Ag did not differ before and after intervention, irrespective of the diets. Our findings suggest postprandial coagulation activation in overweight subjects with more pronounced acute than long-term effects. We observed similar effects of the MUFA diet and the LF diet on the postprandial prothrombotic risk profile. |
| Databáze: | OpenAIRE |
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