Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial – EXPRESSION OF CONCERN
| Autor: | Maedeh Ahmadi-Dastjerdi, Ahmad Esmaillzadeh, Maryam Karamali, Zatollah Asemi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Adolescent Placebo-controlled study Medicine (miscellaneous) chemistry.chemical_element Iran Calcium Gastroenterology Body Mass Index Fetal Macrosomia Double blind Young Adult Double-Blind Method Pregnancy Internal medicine medicine Humans Vitamin D Pregnancy outcomes Cholecalciferol Hyperbilirubinemia Nutrition and Dietetics Vitamin d supplementation Cesarean Section business.industry Body Weight Pregnancy Outcome Public Health Environmental and Occupational Health Correction medicine.disease Calcium Dietary Hospitalization Pregnancy Complications Gestational diabetes Diabetes Gestational chemistry Dietary Supplements Female business Follow-Up Studies |
| Zdroj: | Public Health Nutr |
| ISSN: | 1475-2727 1368-9800 |
| DOI: | 10.1017/s1368980021002573 |
| Popis: | The present study was designed to assess the effects of Ca+vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM).A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca+vitamin D supplements or placebo. Individuals in the Ca+vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D(3)) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined.A urban community setting in Arak, Iran.Sixty women with GDM and their newborns, living in Arak, Iran were enrolled.Women treated with Ca+vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P=0·002) and maternal hospitalization (0 v. 13·3 %, P=0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca+vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P=0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P=0·03) and hospitalization (20·0 % v. 56·7 %, P=0·03) were also seen in the supplemented group of newborns than in the placebo group.Ca+vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns. |
| Databáze: | OpenAIRE |
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