EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities

Autor:	Fernanda R. Badoco, Lucas A.L. Paula, Renato P. Orenha, Tiago M.F. Mendes, Iara S. Squarisi, Nelly El-Sakkary, Messias C. Loiola, Naftale Katz, Denise C. Tavares, Mirela I. Sairre, Renato Luis T. Parreira, Fernanda Janku Cabral, Silmara M. Alegretti, Conor R. Caffrey, Lizandra G. Magalhães
Rok vydání:	2022
Předmět:	Male Mammals Glutathione Peroxidase Curcumin Schistosoma mansoni General Medicine Toxicology Antioxidants Praziquantel Schistosomicides Glutathione Reductase Animals Schistosomiasis Female Reactive Oxygen Species Glutathione Transferase
Zdroj:	Chemico-Biological Interactions. 368:110191
ISSN:	0009-2797
DOI:	10.1016/j.cbi.2022.110191
Popis:	Praziquantel (PZQ) is the only drug available for community-based control programs which aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we synthesized and evaluated the schistosomicidal, biochemical and cytotoxic activities of EF24, a synthetic curcumin analog, against different isolates of Schistosoma mansoni. EF24 elicited marked phenotypic alterations at 10 μM against schistosomula and 42-day-old adult worms of the Naval Medical Research Institute (NMRI) isolate. EF24 had 50% effective concentration (EC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f5848aabe69c932a86a3a8711b735b https://doi.org/10.1016/j.cbi.2022.110191 Zobrazit plný text záznamu Full Text from ScienceDirect