Evaluation of corneal staining and patient preference with use of three multi-purpose solutions and two brands of soft contact lenses
| Autor: | John L. Schachet, Kenneth A Lebow |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Corneal staining Signs and symptoms law.invention Corneal Diseases Cornea law Ophthalmology medicine Humans Aged Cross-Over Studies Staining and Labeling business.industry Middle Aged Contact Lenses Hydrophilic Patient preference Surgery Contact lens Lens (optics) medicine.anatomical_structure Multicenter study Patient Satisfaction Female Fluorescein Contact Lens Solutions business |
| Zdroj: | Eyecontact lens. 29(4) |
| ISSN: | 1542-2321 |
| Popis: | Clinical signs and symptoms vary depending on contact lens brand, lens care products, or a combination of the two. Studies evaluated corneal staining and subject preference associated with three multipurpose solutions (MPS) and two soft contact lens brands.Two sites conducted the randomized, investigator-masked, 2-month crossover studies. Forty-five subjects used regimen 1 (No Rub Opti-Free Express MPS [Alcon, Fort Worth, TX]) and regimen 2 (Complete MPS [Allergan, Irvine, CA]) for 1 month each (study 1). In study 2, 44 subjects used regimen 1 and regimen 3 (ReNu MultiPlus MPS [BauschLomb, Rochester, NY]). ACUVUE 2 (JohnsonJohnson Vision Care, Jacksonville, FL) or SofLens 66 (BauschLomb) lenses were randomly assigned to subjects for the duration of the study. Corneal staining was evaluated on days 0 (baseline), 7, 14, and 28 of each month.Corneal staining was significantly worse with regimen 3 for both lens brands at day 28 compared with baseline (P0.01). Significant differences in staining were noted between regimens 1 and 3 throughout the study, primarily with SofLens 66 lenses (P/= 0.0002). No consistent changes in staining were noted with regimens 1 and 2. Also, significantly more subjects preferred the comfort of regimen 1 (61.8%) to that of regimen 3 (11.8%). More subjects preferred the comfort of regimen 1 (57.1%) to that of regimen 3 (10.7%) compared with their prestudy regimen.These studies showed that chemical variations between lens care systems and their interaction with contact lens materials create significant clinical, physiologic, and subjective preference differences. |
| Databáze: | OpenAIRE |
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