DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool
| Autor: | Nicolas Desbois, Aurélien Laguerre, Claude P. Gros, David Monchaud, Marc Pirrotta, Julien Boudon, Pape Diaba Diabate |
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| Přispěvatelé: | Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Université de Reims Champagne-Ardenne (URCA), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] ( ICMUB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Supramolecular chemistry Nanotechnology [ CHIM ] Chemical Sciences Catalysis 03 medical and health sciences chemistry.chemical_compound energy-transfer Materials Chemistry medicine [CHIM]Chemical Sciences heterocyclic compounds rna Sensitization ComputingMilieux_MISCELLANEOUS visualization ligands aggregation selectivity RNA General Chemistry Fluorescence Porphyrin dye-complexes 030104 developmental biology medicine.anatomical_structure chemistry Biophysics Nucleic acid cells recognition Molecular probe porphyrin DNA |
| Zdroj: | New Journal of Chemistry New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (7), pp.5683-5689. ⟨10.1039/c6nj01012a⟩ New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (7), pp.5683-5689. ⟨10.1039/C6NJ01012A⟩ New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (7), pp.5683-5689. 〈http://pubs.rsc.org/en/content/articlelanding/2016/nj/c6nj01012a#!divAbstract〉. 〈10.1039/c6nj01012a〉 |
| ISSN: | 1144-0546 1369-9261 |
| DOI: | 10.1039/c6nj01012a⟩ |
| Popis: | International audience; The search for convenient molecular probes for detecting DNA and RNA quadruplexes in vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher-order nucleic acid structures play in many genetic dysregulations. Here, we contribute to this search, reporting on a palladated porphyrin named Pd.TEGPy: its efficiency as quadruplex-selective fluorescent dye relies on a structural design that endows it with attractive supramolecular and electronic properties and makes it an efficient turn-on, quadruplex-selective fluorescent stain thanks to a DNA-mediated sensitization mechanism that ensures a high level of specificity. |
| Databáze: | OpenAIRE |
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