Effects of exposure to calves persistently infected with bovine viral diarrhea virus type 1b and subsequent infection with Mannheima haemolytica on clinical signs and immune variables: Model for bovine respiratory disease via viral and bacterial interaction1,2
| Autor: | Marie Montelongo, L. O. Burciaga-Robles, Douglas L. Step, Chris Richards, Robert W. Fulton, Clinton R. Krehbiel, Ben P Holland, Anthony W. Confer |
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| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
Male animal diseases Lymphocyte Bovine respiratory disease Biology Antibodies Viral Body Temperature Andrology Random Allocation chemistry.chemical_compound White blood cell Blood plasma Genetics medicine Animals Interferon gamma Lactic Acid Mannheimia haemolytica Respiratory Tract Infections Sodium bicarbonate Haptoglobins Diarrhea Virus 1 Bovine Viral Respiration Models Immunological General Medicine medicine.disease Antibodies Bacterial Virology Blood Cell Count medicine.anatomical_structure chemistry Blood chemistry Carrier State Absolute neutrophil count Cytokines Bovine Virus Diarrhea-Mucosal Disease Cattle Animal Science and Zoology Pasteurellaceae Infections Food Science medicine.drug |
| Zdroj: | Journal of Animal Science. 88:2166-2178 |
| ISSN: | 1525-3163 0021-8812 |
| DOI: | 10.2527/jas.2009-2005 |
| Popis: | The objective was to determine effects of an intratracheal Mannheimia haemolytica challenge after 72-h exposure to bovine viral diarrhea virus type 1b (BVDV1b) persistently infected (PI) calves on serum antibody production, white blood cell count (WBC), cytokine concentrations, and blood gases in feedlot steers. Twenty-four steers (initial BW = 314 +/- 31 kg) were randomly allocated to 1 of 4 treatments (6 steers/treatment) arranged as a 2 x 2 factorial. Treatments were 1) steers not exposed to steers PI with BVDV nor challenged with M. haemolytica (control; CON); 2) steers exposed to 2 steers PI with BVDV for 72 h (BVD); 3) steers intratracheally challenged with M. haemolytica (MH); and 4) steers exposed to 2 steers PI with BVDV for 72 h and challenged with M. haemolytica (BVD+MH). There were 12 h between exposure to PI steers and challenge with M. haemolytica. Rectal temperature was increased (P < 0.001) for MH and BVD+MH during the initial 24 h after the M. haemolytica challenge. For MH and BVD+MH, total WBC count was increased (P < 0.01) at 36 h post M. haemolytica challenge compared with CON, whereas in BVD steers, WBC count was decreased (P < 0.01). Total lymphocyte count was increased (P = 0.004) during the initial 72 h post BVDV exposure for the BVD and BVD+MH groups compared with MH and CON, and this difference remained at 96 h post M. haemolytica challenge. An increased (P < 0.001) total neutrophil count was observed during the initial 36 h for the MH group and at 72 h for the BVD+MH challenge group. Interleukin 1beta, IL-6, and tumor necrosis factor alpha (TNFalpha) concentrations were greater (P |
| Databáze: | OpenAIRE |
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