Effects of perinatal bisphenol A exposure during early development on radial arm maze behavior in adult male and female rats
| Autor: | Susan L. Schantz, Pul Park, Duncan C. Ferguson, Janice M. Juraska, Renee N. Sadowski, Steven L. Neese |
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| Rok vydání: | 2014 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Offspring Administration Oral Endocrine Disruptors Toxicology Article Cellular and Molecular Neuroscience Follicle-stimulating hormone Phenols Developmental Neuroscience Thyroid-stimulating hormone Pregnancy Internal medicine medicine Animals Weaning Rats Long-Evans Benzhydryl Compounds Maze Learning Radial arm maze urogenital system Hormones Rats Memory Short-Term Endocrinology Endocrine disruptor Prenatal Exposure Delayed Effects Female Follicle Stimulating Hormone Psychology Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Neurotoxicology and Teratology. 42:17-24 |
| ISSN: | 0892-0362 |
| DOI: | 10.1016/j.ntt.2014.01.002 |
| Popis: | Previous work has shown that exposure to bisphenol A (BPA) can affect anxiety behavior. However, no studies have examined whether administration of this endocrine disruptor during the perinatal period has the potential to induce alterations in cognitive behavior in both adult males and females as assessed in an appetitive task. The goal of the current study was to determine whether exposure to different doses of BPA during early development alters performance on the 17-arm radial maze in adulthood in Long-Evans rats. Oral administration of corn oil (vehicle), 4 μg/kg, 40 μg/kg, or 400 μg/kg BPA to the dams occurred daily throughout pregnancy, and the pups received direct oral administration of BPA between postnatal days 1-9. Blood was collected from offspring at weaning age to determine levels of several hormones (thyroxine, thyroid stimulating hormone, follicle stimulating hormone, luteinizing hormone). One male and one female from each litter were evaluated on the 17-arm radial maze, a working/reference memory task, in adulthood. Results indicated that after exposure to BPA at both 4 and 400 μg/kg/day, rats of both sexes had decreased levels of FSH at weaning. There were no significant effects of BPA on performance on the radial arm maze in males or females. In conclusion, exposure to BPA during early development had modest effects on circulating hormones but did not affect performance on a spatial learning and memory task. |
| Databáze: | OpenAIRE |
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