Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia
| Autor: | Yong Xu, Lili Jiang, Zhi Yang, Xi-Nian Zuo, Huijie Li, Xing-Ting Zhu |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Paranoid schizophrenia Adolescent Prefrontal Cortex Young Adult Cellular and Molecular Neuroscience Functional neuroimaging Neural Pathways medicine Humans Age of Onset Child Prefrontal cortex Biological Psychiatry Cerebral Cortex Resting state fMRI Functional Neuroimaging Somatosensory Cortex Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Drug-naïve Schizophrenia Case-Control Studies Connectome Female Schizophrenic Psychology Original Article Occipital Lobe Occipital lobe Psychology Neuroscience medicine.drug |
| Zdroj: | Translational Psychiatry |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/tp.2015.59 |
| Popis: | Schizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficiency of information processing. Distance-related disturbances during development have not been investigated in schizophrenia. To test the distance-related miswiring profiles of connectomes in schizophrenia, we acquired resting-state images from 20 adulthood-onset (AOS) and 26 early-onset schizophrenia (EOS) patients, as well as age-matched healthy controls. All patients were drug naive and had experienced their first psychotic episode. A novel threshold-free surface-based analytic framework was developed to examine local-to-remote functional connectivity profiles in both AOS and EOS patients. We observed consistent increases of local connectivity across both EOS and AOS patients in the right superior frontal gyrus, where the connectivity strength was correlated with a positive syndrome score in AOS patients. In contrast, EOS but not AOS patients exhibited reduced local connectivity within the right postcentral gyrus and the left middle occipital cortex. These regions’ remote connectivity with their interhemispheric areas and brain network hubs was altered. Diagnosis–age interactions were detectable for both local and remote connectivity profiles. The functional covariance between local and remote homotopic connectivity was present in typically developing controls, but was absent in EOS patients. These findings suggest that a distance-dependent miswiring pattern may be one of the key neurodevelopmental features of the abnormal connectome organization in schizophrenia. |
| Databáze: | OpenAIRE |
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