Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan
| Autor: | Keiko Iwai, Ikuro Wakayama, Tameko Kihira, Yuya Arakawa, Ryo Okumura, Yasumasa Kokubo, Kazushi Okamoto, Yuhto Iinuma, Koichi Takamiya, Sohei Yoshida, Iori Sakurai |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Gerontology medicine.disease_cause Mn 03 medical and health sciences 0302 clinical medicine Japan Environmental health Vegetables Internal Medicine Zn Humans Medicine Age of Onset Amyotrophic lateral sclerosis Exercise Life Style Aged Aged 80 and over Farm work Scalp lifestyle change business.industry Incidence Incidence (epidemiology) Amyotrophic Lateral Sclerosis Deoxyguanosine General Medicine medicine.disease Diet Oxidative Stress Kii-ALS 030104 developmental biology 8-Hydroxy-2'-Deoxyguanosine Kii peninsula Lifestyle change Original Article Female business 030217 neurology & neurosurgery Oxidative stress Hair |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.56.8038 |
| Popis: | [Objective] Lifestyle changes may play an important role in the incidence reduction and delay of onset age of amyotrophic lateral sclerosis (ALS) in the Koza/Kozagawa/Kushimoto (K) area. The aim of this study was to evaluate recent lifestyle changes in the K area and to investigate the relationships between lifestyle and oxidative stress among the residents. [Methods] We conducted a medical checkup for elderly residents in the K area and the control area and evaluated the urinary 8-OHdG levels, cognitive function test scores and metal contents in serum and scalp hair, coupled with a lifestyle questionnaire survey between 2010 and 2015. [Results] Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles was associated with high contents of transition metals, such as Mn, Al and V, in the scalp hair. [Conclusion] These lifestyle changes among residents in the K area may be associated with their oxidative stress. |
| Databáze: | OpenAIRE |
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