The WNT signaling pathway from ligand secretion to gene transcription
| Autor: | Reinoud Gosens, Hoeke A. Baarsma, Melanie Königshoff |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
APC TUMOR-SUPPRESSOR
Frizzled Beta-catenin beta-Catenin Transcription Genetic Frizzled (FZD) CATENIN DESTRUCTION COMPLEX Biology Ligands CYSTEINE-RICH DOMAIN GSK-3 Animals Humans Pharmacology (medical) HUMAN COLON-CANCER Wnt Signaling Pathway beta Catenin Pharmacology Lipoprotein receptor related proteins (LRP) NUCLEAR-LOCALIZATION Wnt signaling pathway LRP6 LRP5 GLYCOGEN-SYNTHASE KINASE-3 Dishevelled (DVL) Cell biology Wnt Proteins FRIZZLED-RELATED PROTEIN-1 RECEPTOR-RELATED PROTEIN-5 Biochemistry Axin Casein kinase (CK) biology.protein IDIOPATHIC PULMONARY-FIBROSIS Signal transduction Biogenesis |
| Zdroj: | Pharmacology & Therapeutics. 138(1):66-83 |
| ISSN: | 0163-7258 |
| DOI: | 10.1016/j.pharmthera.2013.01.002 |
| Popis: | Wingless/integrase-1 (WNT) signaling is a key pathway regulating various aspects of embryonic development; however it also underlies several pathological conditions in man, including various cancers and fibroproliferative diseases in several organs. Investigating the molecular processes involved in (canonical) WNT signaling will open new avenues for generating new therapeutics to specifically target diseases in which WNT signaling is aberrantly regulated. Here we describe the complexity of WNT signal transduction starting from the processes involved in WNT ligand biogenesis and secretion by WNT producing cells followed by a comprehensive overview of the molecular signaling events ultimately resulting in enhanced transcription of specific genes in WNT receiving cells. Finally, the possible targets for therapeutic intervention and the available pharmacological inhibitors for this complex signaling pathway are discussed. (C) 2013 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect