Severe systemic cytomegalovirus infections in patients with steroid-refractory ulcerative colitis treated by an oral microemulsion form of cyclosporine: Report of two cases

Autor: Franck Carbonnel, G. Piton, A. C. Dupont-Gossart, Georges Mantion, G. Herbein, G. Viennet, Audrey Weber
Přispěvatelé: Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
Rok vydání: 2008
Předmět:
Adult
MESH: Emulsions
medicine.medical_specialty
medicine.medical_treatment
MESH: Colitis
Ulcerative
Congenital cytomegalovirus infection
Administration
Oral
Context (language use)
medicine.disease_cause
Severity of Illness Index
MESH: Cyclosporine
Gastroenterology
Herpesviridae
03 medical and health sciences
0302 clinical medicine
Betaherpesvirinae
MESH: Severity of Illness Index
Internal medicine
medicine
Humans
MESH: Humans
biology
business.industry
MESH: Adult
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Immunosuppression
MESH: Cytomegalovirus Infections
General Medicine
medicine.disease
biology.organism_classification
Ciclosporin
Ulcerative colitis
3. Good health
Discontinuation
030220 oncology & carcinogenesis
Cytomegalovirus Infections
MESH: Administration
Oral
Immunology
Cyclosporine
Colitis
Ulcerative
Emulsions
Female
030211 gastroenterology & hepatology
MESH: Immunosuppressive Agents
business
MESH: Female
Immunosuppressive Agents
medicine.drug
Zdroj: Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology
Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, Elsevier Masson, 2008, 32 (5 Pt 1), pp.460-4. ⟨10.1016/j.gcb.2007.10.010⟩
ISSN: 0399-8320
DOI: 10.1016/j.gcb.2007.10.010
Popis: International audience; CMV reactivation is frequently observed in acute flares of ulcerative colitis (UC), particularly those which do not respond to intravenous steroids. Several recent series have suggested that, in most cases, CMV reactivation does not lead to severe complications and resolves spontaneously with the UC flare and discontinuation of immunosuppression. In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine. This is of concern, particularly in a context of increasing use of immunosuppressive drugs in UC. We propose a prophylactic and curative approach to decrease morbidity related to CMV infection in active UC.
Databáze: OpenAIRE
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