Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity

Autor:	Davinder Singh, Tenzen Yodun, Gulshan Kumar, Javeed Ahmad Tali, Harshita Tiwari, Jasvinder Singh, Amit Nargotra, Abhilash Samykutty, Shashank Singh, Ravi Shankar
Rok vydání:	2022
Předmět:	Molecular Structure Caspase 3 Pyridines Organic Chemistry Antineoplastic Agents Apoptosis Biochemistry Molecular Docking Simulation Structure-Activity Relationship HEK293 Cells Cell Line Tumor Drug Discovery Humans Drug Screening Assays Antitumor Molecular Biology Cell Proliferation
Zdroj:	Bioorganic Chemistry. 125:105882
ISSN:	0045-2068
Popis:	A library of 49 analogs of imidazo[1,2-a]pyridine with 2-halo, aryl, styryl and phenylethynyl-substitution at C-2 position and N-/O-/S-methyl linkage at C-3 position, have been synthesized and evaluated for their anti-proliferative activity against breast (MCF-7, MDA-MB-231), pancreatic (MiaPaca-2), lung (A549), prostate (PC-3) and colon (HCT-116) cancer cell lines and normal cells (HEK-293). Among the screened compounds, 5b exhibited best anticancer potential in all tested cancer cells with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e0e3a0efd64a49ac73b028cc7336f7 https://doi.org/10.1016/j.bioorg.2022.105882 Zobrazit plný text záznamu Full Text from ScienceDirect