Neoadjuvant chemoradiotherapy could improve survival outcomes for esophageal carcinoma: a meta-analysis
| Autor: | Zhen-Liang Shi, Da-qiang Sun, Xun Zhang, Yi-Jun Xu, Dong-Bin Wang, Hong-Li Han |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty Esophageal Neoplasms Physiology medicine.medical_treatment Subgroup analysis Antineoplastic Agents law.invention Randomized controlled trial law Internal medicine medicine Carcinoma Humans business.industry Gastroenterology Chemoradiotherapy Adjuvant medicine.disease Radiation therapy Meta-analysis Relative risk Adenocarcinoma Radiotherapy Adjuvant business Chemoradiotherapy |
| Zdroj: | Digestive diseases and sciences. 57(12) |
| ISSN: | 1573-2568 |
| Popis: | The effectiveness of neoadjuvant chemoradiotherapy in patients with resectable esophageal carcinoma remains controversial. The purpose of this study was to assess the effect of neoadjuvant chemoradiotherapy on operable esophageal carcinoma. We searched PubMed, EMBASE and Web of Science and identified all randomized controlled trials published up until July 2011 that directly compared chemoradiotherapy followed by surgery with surgery alone. The risk ratio (RR) with its corresponding 95 % confidence interval (CI) was the principal measure of effects. Twelve randomized controlled trials that met our inclusion criteria were identified. Chemoradiotherapy followed by surgery was associated with significantly improved 1-year (RR = 0.86, 95 % CI = 0.74–0.98, P = 0.03), 3-year (RR = 0.82, 95 % CI = 0.73–0.92, P = 0.0007) and 5-year (RR = 0.83, 95 % CI = 0.72–0.96, P = 0.01) survival times compared with surgery alone. Subgroup analysis suggested that this benefit was associated with concurrent chemoradiotherapy but not sequential chemoradiotherapy. Neoadjuvant chemoradiotherapy could improve 3- and 5-year survival outcomes for squamous cell carcinoma but not those for adenocarcinoma. Postoperative morbidity (RR = 0.97, 95 % CI = 0.86–1.09, P = 0.56) and mortality (RR = 1.56, 95 % CI = 0.97–2.50, P = 0.07) did not increase in patients treated by chemoradiotherapy. Our findings revealed that compared with surgery alone, neoadjuvant chemoradiotherapy was associated with improved 1-, 3- and 5-year survival times, but not associated with increased postoperative morbidity and mortality in patients with esophageal carcinoma. |
| Databáze: | OpenAIRE |
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