Caffeoylquinic Acids, Cytotoxic, Antioxidant, Acetylcholinesterase and Tyrosinase Enzyme Inhibitory Activities of Six Inula Species from Bulgaria
| Autor: | Milka Todorova, Gülmira Özek, Miroslav Rangelov, Temel Özek, Veselina Moskova-Doumanova, Tanya Topouzova-Hristova, Antoaneta Trendafilova, Ralitza Veleva, Süleyman Yur, Ina Aneva, Victoria Ivanova, Jordan Doumanov |
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| Přispěvatelé: | Anadolu Üniversitesi |
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
DPPH Cell Survival medicine.medical_treatment Tyrosinase Quinic Acid antioxidant activity Bioengineering Flowers 01 natural sciences Biochemistry Antioxidants Madin Darby Canine Kidney Cells chemistry.chemical_compound Dogs Phenols medicine Animals Humans Food science Enzyme Inhibitors Cytotoxicity Bulgaria Molecular Biology Chromatography High Pressure Liquid Inula biology 010405 organic chemistry Monophenol Monooxygenase Plant Extracts acetylcholinesterase and tyrosinase inhibition caffeoylquinic acids General Chemistry General Medicine Quinic acid biology.organism_classification Acetylcholinesterase 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry chemistry Inula species Molecular Medicine cytotoxicity Methanol |
| Zdroj: | Chemistrybiodiversity. 17(4) |
| ISSN: | 1612-1880 |
| Popis: | Topouzova-Hristova, Tanya/0000-0002-1575-0790; Rangelov, Miroslav/0000-0002-7953-7593 WOS: 000520280700001 PubMed: 32187453 Chlorogenic (5-CQA), 1,5-, 3,5-, 4,5- and 3,4-dicaffeoylquinic (DCQA) acids were identified and quantified in the methanol extracts of Inula oculus-christi L., I. bifrons L., I. aschersoniana Janka var. aschersoniana, I. ensifolia L., I. conyza (Griess.) DC. and I. germanica L. by HPLC analysis. the amount of 5-CQA varied from 5.48 to 28.44 mg/g DE and the highest content was detected in I. ensifolia. 1,5-DCQA (4.05-55.25 mg/g DE) was the most abundant dicaffeoyl ester of quinic acid followed by 3,5-DCQA, 4,5-DCQA and 3,4-DCQA. the extract of I. ensifolia showed the highest total phenolic content (119.92 +/- 0.95 mg GAE/g DE) and exhibited the strongest DPPH radical scavenging activity (69.41 +/- 0.55 %). I. bifrons extract was found to be the most active sample against ABTS(.+) (TEAC 0.257 +/- 0.012 mg/mL) and the best tyrosinase inhibitor. the studied extracts demonstrated a low inhibitory effect towards acetylcholinesterase and possessed low cytotoxicity in concentration range from 10 to 300 mu g/mL toward non-cancer (MDCK II) and cancer (A 549) cells. NSF, Ministry of Education and Science, Bulgaria [DN 09/11] This work was supported by the NSF, Ministry of Education and Science, Bulgaria, Project DN 09/11. |
| Databáze: | OpenAIRE |
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