Immune Function in Critically Ill Septic Children
| Autor: | Mark W. Hall, Katherine Bline |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Inflammation Review Disease Sepsis sepsis Immune system TNFα medicine Immunology and Allergy Intensive care medicine Molecular Biology response General Immunology and Microbiology business.industry Organ dysfunction suppression medicine.disease Pathophysiology Clinical trial modulation Infectious Diseases pediatric inflammation Medicine Tumor necrosis factor alpha medicine.symptom immune business |
| Zdroj: | Pathogens, Vol 10, Iss 1239, p 1239 (2021) Pathogens |
| ISSN: | 2076-0817 |
| Popis: | The inflammatory response in pediatric sepsis is highly dynamic and includes both pro- and anti-inflammatory elements that involve the innate and adaptive immune systems. While the pro-inflammatory response is responsible for the initial clinical signs and symptoms of sepsis, a concurrent compensatory anti-inflammatory response often results in an occult, but highly clinically relevant, form of acquired immunodeficiency. When severe, this is termed “immunoparalysis” and is associated with increased risks for nosocomial infection, prolonged organ dysfunction, and death. This review focuses on the pathophysiology and clinical implications of both over- and under-active immune function in septic children. Host-, disease-, and treatment-specific risk factors for immunoparalysis are reviewed along with immune phenotype-specific approaches for immunomodulation in pediatric sepsis which are currently the subject of clinical trials. |
| Databáze: | OpenAIRE |
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