Receptor-activated modulation in rat cortical slices as measured with a K-sensitive electrode
| Autor: | Gabor Zoltay, Jack R. Cooper |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
2-Chloroadenosine Potassium chemistry.chemical_element In Vitro Techniques Clonidine Ion selective electrode Rats Sprague-Dawley Receptors Adrenergic alpha-2 Internal medicine Parietal Lobe Muscarinic acetylcholine receptor medicine Extracellular Animals Receptor Morphine Chemistry General Neuroscience Purinergic receptor Receptors Purinergic Receptors Muscarinic Electric Stimulation Rats Electrophysiology Endocrinology Receptors Opioid Synapses Biophysics Carbachol Efflux Microelectrodes |
| Zdroj: | Journal of neuroscience methods. 50(2) |
| ISSN: | 0165-0270 |
| Popis: | The effects of a variety of presynaptic receptor-activating modulating agents on potassium efflux have been investigated using a potassium (K)-sensitive extracellular electrode in rat brain cortical slices that are electrically stimulated. Purinergic, α 2 -adrenergic, opioid and muscarinic drugs all increased K outflow. When these agents were used in combination at maximal concentrations, only morphine promoted a further increase in K efflux, suggesting that it utilized a different K channel or acted on cellular elements different from those of the other modulators. |
| Databáze: | OpenAIRE |
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