Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease
| Autor: | Drew R. DeBay, Sultan Darvesh, Earl Martin, George Andrew Reid, Chris V. Bowen, Ian R. Pottie |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Molecular imaging Neuroimaging 123Iodine Single-photon emission computed tomography 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine In vivo Spect imaging medicine Alzheimer mouse model with 5 familial mutations Butyrylcholinesterase medicine.diagnostic_test Chemistry business.industry Magnetic resonance imaging Featured Article Alzheimer's disease Psychiatry and Mental health medicine.anatomical_structure Cerebral cortex Acetylcholinesterase Neurology (clinical) Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia : Translational Research & Clinical Interventions |
| ISSN: | 2352-8737 |
| DOI: | 10.1016/j.trci.2017.01.005 |
| Popis: | Introduction Diagnosis of Alzheimer's disease (AD) in vivo, by molecular imaging of amyloid or tau, is constrained because similar changes can be found in brains of cognitively normal individuals. Butyrylcholinesterase (BChE), which becomes associated with these structures in AD, could elevate the accuracy of AD diagnosis by focusing on BChE pathology in the cerebral cortex, a region of scant BChE activity in healthy brain. Methods N-methylpiperidin-4-yl 4-[123I]iodobenzoate, a BChE radiotracer, was injected intravenously into B6SJL-Tg(APPSwFlLon, PSEN1∗M146 L∗L286 V) 6799Vas/Mmjax (5XFAD) mice and their wild-type (WT) counterparts for comparative single photon emission computed tomography (SPECT) studies. SPECT, computed tomography (CT), and magnetic resonance imaging (MRI) enabled comparison of whole brain and regional retention of the BChE radiotracer in both mouse strains. Results Retention of the BChE radiotracer was consistently higher in the 5XFAD mouse than in WT, and differences were particularly evident in the cerebral cortex. Discussion Cerebral cortical BChE imaging with SPECT can distinguish 5XFAD mouse model from the WT counterpart. |
| Databáze: | OpenAIRE |
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