Dietary polyunsaturated fat intake is associated with low-density lipoprotein size, but not with susceptibility to oxidation in subjects with impaired glucose metabolism and type II diabetes: the Hoorn study

Autor: Giel Nijpels, J.M. Dekker, Tom Teerlink, R.J. Heine, M C Poortvliet, Coen D.A. Stehouwer, Marga C. Ocké, Gerard M. J. Bos, Peter G. Scheffer, Lex M. Bouter
Přispěvatelé: EMGO+ - Lifestyle, Overweight and Diabetes, Other Research in Social Sciences, Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: NUTRIM - R1 - Metabolic Syndrome, RS: CARIM School for Cardiovascular Diseases
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Blood Glucose
Male
medicine.medical_specialty
Saturated fat
Medicine (miscellaneous)
Type 2 diabetes
Carbohydrate metabolism
Cohort Studies
chemistry.chemical_compound
Dietary Fats
Unsaturated
SDG 3 - Good Health and Well-being
Diabetes mellitus
Internal medicine
Surveys and Questionnaires
Glucose Intolerance
Medicine
Humans
Particle Size
Chromatography
High Pressure Liquid
Aged
chemistry.chemical_classification
Aged
80 and over
Nutrition and Dietetics
Cholesterol
business.industry
Cholesterol
LDL
Feeding Behavior
Middle Aged
medicine.disease
Endocrinology
Cross-Sectional Studies
chemistry
Diabetes Mellitus
Type 2
Low-density lipoprotein
Fatty Acids
Unsaturated
Female
lipids (amino acids
peptides
and proteins)
Lipid Peroxidation
business
Oxidation-Reduction
Polyunsaturated fatty acid
Lipoprotein
Zdroj: European Journal of Clinical Nutrition, 61(2), 205-211. Nature Publishing Group
Bos, G, Poortvliet, M C, Scheffer, P G, Dekker, J M, Ocke, M C, Nijpels, G, Stehouwer, C D A, Bouter, L M, Teerlink, T & Heine, R J 2007, ' Dietary polyunsaturated fat intake is associated with low-density lipoprotein size, but not with susceptibility to oxidation in subjects with impaired glucose metabolism and type II diabetes: the Hoorn study ', European Journal of Clinical Nutrition, vol. 61, no. 2, pp. 205-211 . https://doi.org/10.1038/sj.ejcn.1602492
ISSN: 1476-5640
0954-3007
Popis: OBJECTIVE: A high monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) intake is associated with lower plasma low-density lipoprotein (LDL)-cholesterol. However, PUFA may increase the susceptibility of LDL to undergo oxidative modifications. The aim of this study was to analyze the association of habitual dietary fat intake with LDL size and oxidizability. DESIGN: Cross-sectional. SETTING: Cohort study. SUBJECTS: Seven hundred and fifty-eight subjects with normal, impaired glucose metabolism and type II diabetes. INTERVENTIONS: Mean LDL size was measured by high-performance gel-filtration chromatography. In vitro oxidizability of LDL was determined by measuring lag time, reflecting the resistance of LDL to copper-induced oxidation. Information about dietary fat intake was obtained by a validated food frequency questionnaire. RESULTS: PUFA intake (energy percent) was significantly and negatively associated with LDL size in subjects with type II diabetes (standardized beta (95% confidence interval) -0.17 (-0.28;-0.06)) and impaired glucose metabolism - although not statistically significant - (-0.09 (-0.24;0.05)), but not in subjects with normal glucose metabolism (0.01 (-0.10;0.12)) (P-value for interaction=0.02). No significant associations were observed for total, saturated fat and MUFA intake with LDL size. Intake of fat was associated with lag time; however, the small magnitude of the associations suggested that the composition of dietary fat is not a major factor affecting lag time. The same association with lag time was observed in all three glucose metabolism categories. CONCLUSIONS: In individuals with abnormal glucose metabolism, higher PUFA intake is associated with smaller LDL particle size, but does not alter the susceptibility of LDL to in vitro oxidation. SPONSORSHIP: Dutch Diabetes Research Foundation, and the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).
Databáze: OpenAIRE
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