Post COVID-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis
| Autor: | Alfredo Insausti-García, José Alberto Reche-Sainz, Daniela Ximena Rojas-Correa, Cristina Calleja-García, Manuel Ferro-Osuna |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
biology business.industry viruses Neurotropism Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus diseases Case Reports medicine.disease Virology Myelin oligodendrocyte glycoprotein 03 medical and health sciences Ophthalmology 0302 clinical medicine 030221 ophthalmology & optometry medicine biology.protein Optic neuritis Neurology (clinical) Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Neuroophthalmology |
| ISSN: | 1744-506X 0165-8107 |
| DOI: | 10.1080/01658107.2021.1916044 |
| Popis: | Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by autoimmune mechanisms. We herein report the case of a 69-year-old diabetic male who presented with bilateral sub-acute, progressive loss of vision 45 days after suffering a presumed SARS-CoV-2 related pneumonia. He had bilateral optic disc oedema. Magnetic resonance imaging showed uniform contrast enhancement of both optic nerves without spinal cord involvement. He tested positive for SARS-CoV-2 IgG and myelin oligodendrocyte glycoprotein (MOG) IgG antibodies. He was treated with intravenous methylprednisolone for 5 days. The optic disc oedema resolved within 6 weeks with improvement in visual acuity, although optic atrophy developed by week 16. The MOG-IgG antibody test turned negative after 24 weeks. |
| Databáze: | OpenAIRE |
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