Statin treatment is associated with reduced thermal heterogeneity in human atherosclerotic plaques
| Autor: | Kostas Toutouzas, Manolis Vavuranakis, D B Panagiotakos, Sophia Vaina, Eleutherios Tsiamis, Dimitrios Tousoulis, Christodoulos Stefanadis, P.K. Toutouzas, C. Pitsavos |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Hot Temperature Statin Arteriosclerosis medicine.drug_class Culprit Lesion Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Retrospective Studies Unstable angina business.industry Vascular disease Retrospective cohort study Middle Aged medicine.disease Coronary Vessels Surgery Thermography Multivariate Analysis Cardiology Female Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal. 23:1664-1669 |
| ISSN: | 0195-668X |
| DOI: | 10.1053/euhj.2002.3174 |
| Popis: | Aims Heat released from atherosclerotic plaques as a result of the local inflammatory process, may be measured in vivo by a thermography catheter. Statins seem to have an antiinflammatory effect which results in plaque stabilization. The aim of this study was to investigate the effect of statins on plaque temperature. Methods and Results The study population included 72 patients: 21 with effort angina, 32 with unstable angina and 19 with acute myocardial infarction. In the study group, 37 patients received statins for more than 4 weeks and 35 were not receiving statins. We measured the temperature difference (ΔT) between the atherosclerotic plaque and the proximal vessel wall (background temperature) using a thermography catheter. The statistical analysis showed that the mean value of ΔT was higher in the untreated group compared to the treated-with-statin, group (0·56±0·41 vs 0·29±0·33°C, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|