Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea
| Autor: | C Georgala, K Aroni, Elma Koumantaki-Mathioudaki, S. Georgala, Alexander C. Katoulis, GD Kylafis |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Dermatology Sensitivity and Specificity Cohort Studies Papulopustular Demodex brevis Reference Values Risk Factors parasitic diseases Mite Prevalence Medicine Animals Humans Hypersensitivity Delayed Aged Skin Mites biology business.industry Case-control study Middle Aged biology.organism_classification medicine.disease Immunohistochemistry Demodex folliculorum Microscopy Electron Infectious Diseases Delayed hypersensitivity Rosacea Case-Control Studies Immunology Etiology Female business |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology : JEADV. 15(5) |
| ISSN: | 0926-9959 |
| Popis: | Background Rosacea is a common chronic dermatosis that evolves in stages. The mite Demodex folliculorum has been implicated in its obscure aetiopathogenesis. Aim To evaluate the importance of D. folliculorum in the aetiology and course of rosacea. Methods We studied 92 consecutive cases of papulopustular rosacea and 92 age- and sex-matched controls. Prevalence and density of D. folliculorum were estimated by microscopic examination of the expressed follicular content. Histological examination and immunohistochemical study of the inflammatory infiltrate were performed in 10 subjects (five with positive D. folliculorum finding and five with negative finding). Results D. folliculorum was detected in 83 (90.2%) of the 92 rosacea subjects but only 11 (11.9%) of the controls. The mean mite density was 2.03 mites/visual field in the rosacea group (range 0–5, SD = 1.2) and 0.16 mites/visual field (range 0–2, SD = 0.52) in the control group. The difference was statistically significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text