Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism
| Autor: | Michele Bardini, Gino Santoro, Lorenzo Ghiadoni, Antonio Salvetti, Matteo Bernini, Fabio Galetta, Ferdinando Franzoni, Giampaolo Bernini, Chiara Taurino, M. Bernardini |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Physiology Carotid arteries Primary aldosteronism Fibrosis Internal medicine Hyperaldosteronism Internal Medicine medicine Humans In patient Pulse wave velocity Aorta Ultrasonography business.industry Middle Aged medicine.disease Elasticity Femoral Artery medicine.anatomical_structure Carotid Arteries Intima-media thickness Regional Blood Flow Case-Control Studies Pulsatile Flow Hypertension Radial Artery cardiovascular system Cardiology Arterial stiffness Female Cardiology and Cardiovascular Medicine business Tunica Intima Tunica Media Artery |
| Zdroj: | Journal of hypertension. 26(12) |
| ISSN: | 0263-6352 |
| Popis: | To evaluate vascular wall structure and conduit artery stiffness in patients with primary aldosteronism.This observational study, conducted in a University Hypertension Center, evaluated the carotid wall by 2-D ultrasonography and ultrasonic tissue characterization, and analyzed arterial stiffness by applanation tonometer. Twenty-three consecutive patients with primary aldosteronism, 24 matched patients with essential hypertension and 15 controls were studied. Intima-media thickness and corrected integrated backscatter signal of the carotid arteries were evaluated. Radial and femoral pulse wave velocity and aortic augmentation index were also investigated.Intima-media thickness in patients with essential hypertension (0.69 +/- 0.03 mm) was higher (P0.04) than that in controls (0.59 +/- 0.02 mm). This finding was more evident in primary aldosteronism patients (0.84 +/- 0.03 mm), in whom intima-media thickness was greater than that in controls (P0.0001) or in patients with essential hypertension (P0.01). Similarly, corrected integrated backscatter signal in patients with essential hypertension (-23.6 +/- 0.35 dB) was higher (P0.0001) than that in controls (-26.2 +/- 0.44 dB), but it was even more elevated in patients with primary aldosteronism (-22.1 +/- 0.46 dB), who showed greater corrected integrated backscatter signal than was the case in patients with essential hypertension (P0.009) or in controls (P0.0001). Femoral pulse wave velocity was higher in primary aldosteronism patients (10.8 +/- 0.57 m/s) than in patients with essential hypertension (9.1 +/- 0.34 m/s, P0.03) or in controls (7.1 +/- 0.51 m/s, P0.0001). Femoral pulse wave velocity was lower in controls than in patients with essential hypertension (P0.0001). The same pattern was observed for radial pulse wave velocity. Aortic augmentation index was higher in primary aldosteronism patients (28.2 +/- 2.1%) than in patients with essential hypertension (26.0 +/- 1.8%) or in controls (16.8 +/- 2.0%, P0.001). Patients with essential hypertension likewise exhibited higher aortic augmentation index than controls (P0.001).Aldosterone excess is responsible per se for vascular morphological (wall thickening and carotid artery fibrosis) and functional (central stiffness) damage. |
| Databáze: | OpenAIRE |
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