The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice
| Autor: | Michael V. Callahan, Kelly L. Warfield, Dale L. Barnard, Donald F. Smee, Craig W. Day, Mansoora Khaliq, Sven Enterlein, Aruna Sampath, Urban Ramstedt |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
1-Deoxynojirimycin mice 030106 microbiology lcsh:QR1-502 Iminosugar Biology medicine.disease_cause Antiviral Agents lcsh:Microbiology Dengue fever 03 medical and health sciences chemistry.chemical_compound UV-4B Orthomyxoviridae Infections In vivo Virology human bronchial epithelial cells Influenza A virus medicine Animals Humans Cells Cultured Communication Endoplasmic reticulum Body Weight virus diseases Epithelial Cells Influenza a medicine.disease Survival Analysis antiviral Disease Models Animal Influenza B virus Treatment Outcome 030104 developmental biology Infectious Diseases chemistry influenza Ex vivo |
| Zdroj: | Viruses Viruses, Vol 8, Iss 3, p 71 (2016) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v8030071 |
| Popis: | Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in mice. In the current study, the breadth of activity of UV-4B against influenza was examined ex vivo and in vivo. Efficacy of UV-4B against influenza A and B viruses was shown in primary human bronchial epithelial cells, a principal target tissue for influenza. Efficacy of UV-4B against influenza A (H1N1 and H3N2 subtypes) and influenza B was demonstrated using multiple lethal mouse models with readouts including mortality and weight loss. Clinical trials are ongoing to demonstrate safety of UV-4B and future studies to evaluate antiviral activity against influenza in humans are planned. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|