A prospective pilot study of the effect of neutrophil elastase on the pulmonary vascular permeability in patients with pneumonia
| Autor: | Mariko Omura, H Hirama, Hiroyuki Yokota, Tomohiko Masuno, Shigeki Kushimoto, K Yonezawa, Takashi Tagami, Yasuhiro Yamamoto, G Akiyama, Ryoichi Tosa |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology ARDS biology business.industry Vascular permeability Lung injury Critical Care and Intensive Care Medicine medicine.disease Gastroenterology respiratory tract diseases Hypoxemia Pulmonary vascular permeability Pneumonia Internal medicine Neutrophil elastase Poster Presentation medicine biology.protein In patient medicine.symptom business |
| Zdroj: | Critical Care |
| ISSN: | 1466-609X 1364-8535 |
| Popis: | Some cases of pneumonia may lead to hypoxemia with acute respiratory failure, acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), which may require intensive management. Neutrophil elastase is thought to be one of the causes of ALI/ARDS, because it raises the pulmonary capillary permeability, lyses of pulmonary connective tissue proteins, and produces leukocyte chemotactic factors. However, a causal relationship between the plasma neutrophil elastase level and changes in the pulmonary capillary permeability has not been established in patients with pneumonia, one of the most serious diseases underlying ALI/ARDS. Therefore, the objective of this study was to determine whether an increase in plasma neutrophil elastase is related to elevation of the pulmonary capillary permeability in patients with pneumonia. |
| Databáze: | OpenAIRE |
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