Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways
Autor: | Jung Hwan Shin, Min Song, Se-Bum Paik, Min Whan Jung |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Multidisciplinary Movement (music) Movement Spatial Behavior Classical conditioning Mice Transgenic Striatum Biological Sciences Biology Corpus Striatum 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Calcium imaging Reward nervous system Basal ganglia Animals Direct pathway of movement Calcium Signaling Neuroscience 030217 neurology & neurosurgery Movement control Spatial organization |
Zdroj: | Proc Natl Acad Sci U S A |
ISSN: | 1091-6490 0027-8424 |
Popis: | To obtain insights into striatal neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatal neurons related to movement and reward-based learning. For this, we recorded the activity of direct- and indirect-pathway neurons (D1 and A2a receptor-expressing neurons, respectively) in mice engaged in probabilistic classical conditioning and open-field free exploration. We found broadly organized functional clusters of striatal neurons in the direct as well as indirect pathways for both movement- and reward-related variables. Functional clusters for different variables were partially overlapping in both pathways, but the overlap between outcome- and value-related functional clusters was greater in the indirect than direct pathway. Also, value-related spatial clusters were progressively refined during classical conditioning. Our study shows the broad and learning-dependent spatial organization of functional clusters of dorsal striatal neurons in the direct and indirect pathways. These findings further argue against the classic model of the basal ganglia and support the importance of spatiotemporal patterns of striatal neuronal ensemble activity in the control of behavior. |
Databáze: | OpenAIRE |
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