L-Carnitine Supplementation does not Promote Weight Loss in Ovariectomized Rats Despite Endurance Exercise
| Autor: | Michael J. Keenan, A Schaffhauser, K Owen, Carol E. O'Neil, José María Fernández, S A Melton, L L LaMotte, C E Stanciu, E M Zablah-Pimentel, M Hegsted, Rhonda D. Prisby, P Gaynor |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Ovariectomy Endocrinology Diabetes and Metabolism Physical Exertion Medicine (miscellaneous) Adipose tissue Physical exercise Rats Sprague-Dawley Endurance training Weight loss Carnitine Internal medicine Abdomen Weight Loss medicine Animals Swimming Nutrition and Dietetics business.industry General Medicine medicine.disease Diet Rats Menopause Endocrinology Adipose Tissue Dietary Supplements Body Composition Physical Endurance Ovariectomized rat Female medicine.symptom business Weight gain medicine.drug |
| Zdroj: | International Journal for Vitamin and Nutrition Research. 75:156-160 |
| ISSN: | 1664-2821 0300-9831 |
| DOI: | 10.1024/0300-9831.75.2.156 |
| Popis: | In this five-week study, we tested the hypotheses that free access to a maintenance diet supplemented with L-carnitine (L-C) would reduce body fat in adult, sedentary, ovariectomized (OVX) rats, and that there would be an additive effect of L-C on weight reduction in swim-trained animals. As expected, serum carnitine was higher in rats fed the L-C diet, and the OVX-induced weight gain and abdominal fat were counteracted by swimming. L-C supplementation did not reduce the weight gain or abdominal fat in these adult female rats. Moreover, though not reaching statistical significance, rats that were fed L-C demonstrated a tendency for greater weight gain than their basal-fed counterparts despite no difference in energy intake. If the results of this study on ovariectomized rats can be translated to postmenopausal women, moderate intensity exercise may be recommended, but L-C supplementation, with no energy restriction, may be contraindicated as a weight loss method in this cohort. |
| Databáze: | OpenAIRE |
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