Photolabile Protecting Groups Based on the Excited State Meta Effect: Development and Application †

Autor:	Pengfei Wang, Chaeeun Lim
Rok vydání:	2022
Předmět:	General Medicine Physical and Theoretical Chemistry Biochemistry
Zdroj:	Photochemistry and Photobiology. 99:221-234
ISSN:	1751-1097 0031-8655
Popis:	This review focuses on utilization of the excited state meta effect (ESME) in the development of photolabile protecting groups (PPGs). Structurally simple ESME-based PPGs for release of various functional groups (such as carbonyl, hydroxyl, carboxyl, amino and thiol groups) are discussed. Examples that demonstrate the appealing advantages of these new PPGs are provided, including their efficient release of "poor" leaving groups such as hydroxyl or amino group directly instead of in their respective carbonate or carbamate form. Applications of these PPGs in synthesis, release of biologically important molecules, materials science and biomedical engineering are also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d261089e4e9ca8f2800beed03558eb https://doi.org/10.1111/php.13690 Zobrazit plný text záznamu Plný text