Resting-State Networks of Adolescents Experiencing Depersonalization-Like Illusions: Cross-sectional and Longitudinal Findings

Autor: Sophie Schwartz, Dimitri Van De Ville, Martin Debbané, Melodie Derome, Eduardo Fonseca-Pedrero, Stephan Eliez, Larisa Morosan, Deborah Myriam Badoud, François Lazeyras, Raymond C.K. Chan, David Rudrauf
Rok vydání: 2018
Předmět:
Male
Schizotypy
Audiology
schizotypal personality
default mode network
ddc:616.89
self
0302 clinical medicine
ddc:150
Depersonalization
psychosis
Longitudinal Studies
Child
Default mode network
media_common
Cerebral Cortex
Brain Mapping
05 social sciences
Illusions
Magnetic Resonance Imaging
the-mirror illusion
Invited Theme Articles
Psychiatry and Mental health
Schizophrenia
Visual Perception
Female
medicine.symptom
Psychology
Adult
medicine.medical_specialty
Psychosis
Adolescent
media_common.quotation_subject
schizotypy
Illusion
ultra-high risk
object recognition
050105 experimental psychology
Young Adult
03 medical and health sciences
1st-episode psychosis
mirror task
medicine
Humans
Personality
0501 psychology and cognitive sciences
Resting state fMRI
functional connectivity
face
medicine.disease
ddc:616.8
schizophrenia
Cross-Sectional Studies
Nerve Net
030217 neurology & neurosurgery
Zdroj: Schizophrenia Bulletin (2018)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
ISSN: 1745-1701
0586-7614
DOI: 10.1093/schbul/sby031
Popis: The mirror-gazing task (MGT) experimentally induces illusions, ranging from simple color changes in the specular image of oneself, to depersonalization-like anomalous self-experiences (ASE) as in experiencing one's specular image as someone else. The objective was to characterize how connectivity in resting-state networks (RSNs) differed in adolescents reporting such depersonalization-like ASEs during the MGT, in a cross-sectional (Y1) and in a longitudinal manner (a year after). 75 adolescents were recruited; for the cross-sectional analysis, participants were split into 2 groups: those who reported depersonalization-like ASEs on the MGT (ASE), and those who did not (NoASE). For the longitudinal analysis, participants were split into 3 groups whether they experienced MGT depersonalization-like ASEs: only at Y1 (Remitters), both times (Persisters), or never (Controls). Participants also filled out self-reports assessing schizotypal personality (Schizotypal Personality Questionnaire [SPQ]), and underwent resting-state functional MRI procedure (rs-fMRI). A group level Independent Component Analysis (ICA) was conducted and voxel-wise inter-group differences within RSNs were examined. The rs-fMRI analysis revealed lower connectivity of specific visual areas within the primary visual network (PVN), and higher connectivity of regions within the Default Mode Network (DMN) when contrasting the ASE and NoASE groups. The areas that were atypically connected within the PVN further presented differential pattern of connectivity in the longitudinal analysis. Atypical connectivity of visual area within the DMN at Y1 was associated with higher scores on the disorganized dimension of schizotypy at the second evaluation. The present study uncovers a subtle signature in the RSNs of non-clinical adolescents who experienced task-induced ASEs.
Databáze: OpenAIRE
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