ASYMMETRIC HYDROXYCHLOROQUINE MACULAR TOXICITY WITH APHAKIC FELLOW EYE
| Autor: | R.C. Andrew Symons, Wilson J. Heriot, Heather G Mack, Dujon R.W. Fuzzard |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug
medicine.medical_specialty genetic structures media_common.quotation_subject Aphakia Postcataract 01 natural sciences Retina Melanin Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Retinal Diseases Ophthalmology Lens Crystalline medicine Humans 0101 mathematics Drug toxicity media_common Retinal pigment epithelium business.industry 010102 general mathematics Hydroxychloroquine General Medicine Middle Aged medicine.disease eye diseases medicine.anatomical_structure Rheumatoid arthritis Antirheumatic Agents Toxicity 030221 ophthalmology & optometry Visual Field Tests Female sense organs Visual Fields business Tomography Optical Coherence medicine.drug Retinopathy |
| Zdroj: | Retinal casesbrief reports. 15(2) |
| ISSN: | 1937-1578 |
| Popis: | Background/purpose Retinal toxicity associated with antimalarial drug use in inflammatory conditions is well described and may be more common than previously recognized. Antimalarial drugs bind to melanin in ocular tissues, particularly the retinal pigment epithelium, but the mechanism of toxicity and its relation to light is unclear. Methods Case report. Results A 62-year-old white woman with erosive rheumatoid arthritis developed hydroxychloroquine toxicity in her phakic eye, with her aphakic fellow eye only mildly affected. Conclusion We report the clinical evaluation of this rare case of asymmetrical hydroxychloroquine retinopathy and present a hypothesis regarding the mechanism of drug toxicity. |
| Databáze: | OpenAIRE |
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