Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis
| Autor: | Koki Hikami, Yukikazu Ehara, Kazuhiko Takehara, Katsushi Tokunaga, Takanori Oka, Masaki Matsushita, Shinichi Sato, Manabu Fujimoto, Minoru Hasegawa, Naoyuki Tsuchiya |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Linkage disequilibrium Biophysics Biology Biochemistry Polymorphism Single Nucleotide Linkage Disequilibrium Interferon Genotype medicine SNP Humans Genetic Predisposition to Disease Allele Receptor Molecular Biology Cell Biology Middle Aged Interleukin-10 Receptor beta Subunit Interleukin-10 Interleukin 10 Immunology I antibody Scleroderma Diffuse ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female medicine.drug |
| Zdroj: | Biochemical and biophysical research communications. 373(3):403-407 |
| ISSN: | 0006-291X |
| Popis: | application/pdf Interleukin-10 (IL-10) signaling has been suggested to play a role in systemic sclerosis (SSc). IL10RB codes for IL-10 receptor 2 (IL-10R2), a component shared in receptor complexes for IL-10, IL-22, IL-26 and interferon (IFN)-λ. In this study, we examined association of IL10RB polymorphism with susceptibility to SSc. Genotype A/A at rs2834167 (47K/K) was significantly increased in diffuse cutaneous SSc (dcSSc) (41.3% in dcSSc, 20.9% in controls, P = 0.0018, odds ratio = 2.67). A SNP in the 5′ flanking region of IL10RB, rs999788, also showed association with dcSSc; however, this association was shown to be secondarily caused by linkage disequilibrium with rs2834167. Significant association was not observed in limited cutaneous SSc (lcSSc). Presence of anti-topoisomerase I antibody was also associated with rs2834167A/A genotype (P = 0.0019). Serum IL-10 level was significantly associated with the number of rs2834167A allele (P = 0.007). These findings suggested that signaling through IL-10R2 may play a causative role in dcSSc. |
| Databáze: | OpenAIRE |
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