Additional file 1 of Genetic susceptibility to multiple sclerosis: interactions between conserved extended haplotypes of the MHC and other susceptibility regions

Autor: Goodin, D. S., Khankhanian, P., Gourraud, P. A., Vince, N.
Rok vydání: 2021
Předmět:
DOI: 10.6084/m9.figshare.14954456
Popis: Additional file 1: This Supplemental File describes composition of the CEHs found in the WTCCC dataset as well as their individual relationships to MS susceptibility, the impact on susceptibility of various combinations either of CEHs at the MHC or of the non-MHC loci and, finally, how this CEH composition differs between populations around the world. Furthermore, this file considers the theoretical underpinnings for the commonly used additive and multiplicative Models for the accumulation of disease “risk” with increasing number of “risk haplotypes” being present in an individual’s genotype.
Databáze: OpenAIRE