Target Cell Populations of Human Immunodeficiency Virus Type 1 in Peripheral Blood Lymphocytes with Different Chemokine Receptors at Various Stages of Disease Progression
| Autor: | Chantapong Wasi, Surapol Suwanagool, Kantima Sangsiriwut, Prasert Auewarakul |
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| Rok vydání: | 2001 |
| Předmět: |
Receptors
CXCR4 Receptors CCR5 viruses Lymphocyte Molecular Sequence Data Immunology Population HIV Infections HIV Envelope Protein gp120 Biology V3 loop Microbiology CXCR4 chemistry.chemical_compound Chemokine receptor Proviruses Virology medicine Humans Amino Acid Sequence education education.field_of_study virus diseases Viral Load Phenotype Peptide Fragments CD4 Lymphocyte Count Cross-Sectional Studies medicine.anatomical_structure chemistry Insect Science DNA Viral Disease Progression HIV-1 Leukocytes Mononuclear Pathogenesis and Immunity Receptors Chemokine Sequence Alignment Viral load DNA |
| Zdroj: | Journal of Virology. 75:6384-6391 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.75.14.6384-6391.2001 |
| Popis: | We studied the distribution of human immunodeficiency virus type 1 (HIV-1) DNA in CCR5-positive and -negative peripheral blood lymphocyte populations in HIV-1-infected individuals. While HIV-1 DNA in the CCR5-positive population showed no correlation with CD4 count, the increase of total HIV-1 DNA with lower CD4 count was mainly contributed by the increase of HIV-1 DNA in the CCR5-negative population. This might indicate the change in coreceptor usage from CCR5 to CXCR4 in later stages of disease progression. However, some of the samples with a high viral DNA load in the CCR5-negative population did not have any characteristic of the V3 loop sequence that is compatible with CXCR4 usage or the syncytium-inducing (SI) phenotype. We also did not find any known characteristic change predictive of the SI phenotype in V1 and V2 sequences. Our findings showed that there might be a shift in target cell populations during disease progression, and this shift was not necessarily associated with the genetic changes characteristic of CXCR4 usage. |
| Databáze: | OpenAIRE |
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