Rapid serological tests for SARS-CoV-2 IgG/IgM - not worth attention?
| Autor: | Piotr M. Stępień, Rafał Krygier, Dorota Zarębska-Michaluk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Igm antibody rt-pcr Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Antibodies Viral Asymptomatic rapid serological tests Serology Internal medicine Pandemic medicine Humans Pandemics business.industry SARS-CoV-2 screening Public Health Environmental and Occupational Health COVID-19 Nasopharyngeal swab (specimen) General Medicine Middle Aged Current analysis employees Immunoglobulin M Immunoglobulin G Medicine Female medicine.symptom business |
| Zdroj: | International Journal of Occupational Medicine and Environmental Health, Vol 34, Iss 2, Pp 203-209 (2021) |
| ISSN: | 1896-494X |
| Popis: | OBJECTIVES: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2) had spread worldwide since December 2019 and became a pandemic in March 2020. The diagnosis of an active infection is based on the real-time reverse transcriptase-polymerase chain reaction (RT-PCR) from the nasopharyngeal swab specimen. The aim of the current analysis was to assess the usefulness of the rapid serological tests for diagnosing SARS-CoV-2 infections. MATERIAL AND METHODS: The rapid serological tests detecting IgG/IgM antibodies for SARS-CoV-2 were voluntarily performed in asymptomatic employees of 2 companies. The examination was conducted at the date and time selected online by the study participants. The testing team consisted of 2 nurses collecting the samples and 1 doctor who interpreted the results. Each positive rapid test result was verified by an RT-PCR examination from a nasopharyngeal swab. The testing kits named Vazyme: 2019-nCoV IgG/IgM Detection Kit (Colloidal Gold-Based) were provided by the employer along with the manual and certificates. RESULTS: The overall interest in testing among employees was below the employer's expectations and reached 30% and 20% in each of the 2 companies, respectively. A total of 516 participants were included in the analysis. Ten positive results of the rapid tests were documented, including 7 for IgM and 3 for IgG antibodies. No positive result was confirmed by the detection of the genetic material of the SARS-CoV-2 by the RT-PCR examination. CONCLUSIONS: Herein, the authors demonstrated the uselessness of rapid serological tests performed in asymptomatic volunteers for diagnosing SARS-CoV-2 infections. Int J Occup Med Environ Health. 2021;34(2):203-9. |
| Databáze: | OpenAIRE |
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