Neuroimaging of juvenile pilocytic astrocytomas: an enigma
| Autor: | J Nishimiya, J W Melisi, Andrew J. Dwyer, G. Di Chiro, Michael J. Fulham |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Gadolinium DTPA Male Fluorine Radioisotopes Pathology medicine.medical_specialty Adolescent Pilocytic Astrocytomas Contrast Media Gadolinium Astrocytoma Deoxyglucose Meglumine Neuroimaging Fluorodeoxyglucose F18 Organometallic Compounds medicine Humans Radiology Nuclear Medicine and imaging neoplasms Fluorodeoxyglucose medicine.diagnostic_test Brain Neoplasms business.industry Disease progression Age Factors Pentetic Acid medicine.disease Magnetic Resonance Imaging Drug Combinations Contrast medium Glucose Positron emission tomography Female Tomography X-Ray Computed business Follow-Up Studies Tomography Emission-Computed medicine.drug Anaplastic astrocytoma |
| Zdroj: | Radiology. 189:221-225 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.189.1.8372197 |
| Popis: | To present the imaging, metabolic, and clinical data obtained in five patients with juvenile pilocytic astrocytomas (JPAs) and discuss the paradoxical neuroimaging findings.Five patients with JPAs who had undergone structural imaging and fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) were studied. Normalized glucose utilization rates (GURs) in the tumor were compared with GURs in histopathologically verified low-grade astrocytomas and high-grade tumors.All JPAs enhanced markedly after administration of contrast medium. Their glucose metabolism was significantly (P.001) higher than that of low-grade astrocytomas and was similar to that of anaplastic astrocytomas. All patients with JPAs were in stable condition and showed no evidence of disease progression despite contrast enhancement and high tumoral glucose metabolism.The paradoxical FDG PET findings and enhancement at structural imaging might reflect the unusual vascularity of pilocytic tumors, and the increased GUR might be related to expression of the glucose transporter. |
| Databáze: | OpenAIRE |
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