The theranostic efficiency of tumor-specific, pH-responsive, peptide-modified, liposome-containing paclitaxel and superparamagnetic iron oxide nanoparticles
| Autor: | Xiao-Chuan Duan, Shuang Zhang, Xuan Zhang, Yi-Fan Yin, Wei Ren, Zhan-Tao Li, Hui Li, Yan-Li Hao, Man Liu, Mei-Qi Xu, Ting Zhong, Zhuo-Yue Li, Xiu-Chai Zheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Theranostic Nanomedicine Pharmaceutical Science 02 engineering and technology Ferric Compounds chemistry.chemical_compound tumor-specific pH-responsive peptide International Journal of Nanomedicine Neoplasms Drug Discovery Tissue Distribution Magnetite Nanoparticles Original Research Liposome Mice Inbred BALB C medicine.diagnostic_test Cell Death Chemistry superparamagnetic iron oxide nanoparticles General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Ligand (biochemistry) Flow Cytometry Magnetic Resonance Imaging Paclitaxel liposome Female 0210 nano-technology Preclinical imaging theranostic efficiency Biophysics Mice Nude Bioengineering Antineoplastic Agents Flow cytometry Biomaterials 03 medical and health sciences In vivo Cell Line Tumor medicine Animals Humans Organic Chemistry In vitro Drug Liberation 030104 developmental biology Liposomes Cancer research Peptides |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 1176-9114 |
| Popis: | Xiu-Chai Zheng,1,2,* Wei Ren,1,2,* Shuang Zhang,1,2 Ting Zhong,1,2 Xiao-Chuan Duan,1,2 Yi-Fan Yin,1,2 Mei-Qi Xu,1,2 Yan-Li Hao,1,2 Zhan-Tao Li,1,2 Hui Li,1,2 Man Liu,1,2 Zhuo-Yue Li,1,2 Xuan Zhang1,2 1Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China; 2Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China *These authors contributed equally to this work Background: In the present study, the tumor-specific, pH-responsive peptide H7K(R2)2 -modified, theranostic liposome-containing paclitaxel (PTX) and superparamagnetic iron oxide nanoparticles (SPIO NPs), PTX/SPIO-SSL-H7K(R2)2, was prepared by using H7K(R2)2 as the targeting ligand, SPIO NPs as the magnetic resonance imaging (MRI) agent, PTX as antitumor drug. Methods: The PTX/SPIO-SSL-H7K(R2)2 was prepared by a thin film hydration method. The characteristics of PTX/SPIO-SSL-H7K(R2)2 were evaluated. The targeting effect, MRI, and antitumor activity of PTX/SPIO-SSL-H7K(R2)2 were investigated detail in vitro and in vivo in human breast carcinoma MDA-MB-231 cell models. Results: Our results of in vitro flow cytometry, in vivo imaging, and in vivo MR imaging confirmed the pH-responsive characteristic of H7K(R2)2 in MDA-MB-231 cell line in vitro and invivo. The results of in vivo MRI and in vivo antitumor activity confirmed the theranostic effect of PTX/SPIO-SSL-H7K(R2)2 in MDA-MB-231 tumor-bearing model. Conclusion: Considering all our in vitro and in vivo results, we conclude that we developed targeting modified theranostic liposome which could achieve both role of antitumor and MRI. Keywords: tumor-specific pH-responsive peptide, paclitaxel, superparamagnetic iron oxide nanoparticles, liposome, theranostic efficiency |
| Databáze: | OpenAIRE |
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