Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance
| Autor: | Joshua A. Stern, Mariellen E. Dentino, William D. Tyrrell, Steven L. Rosenthal, Samantha L. Fousse, Frances L. Abrams |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:QH426-470
040301 veterinary sciences biology.animal_breed Disease Breeding Canine 0403 veterinary science 03 medical and health sciences Irish lcsh:Zoology Genetics Dog Medicine lcsh:QL1-991 030304 developmental biology 0303 health sciences biology business.industry Research Inheritance (genetic algorithm) Irish wolfhound Atrial fibrillation 04 agricultural and veterinary sciences General Medicine Heritability medicine.disease Breed language.human_language lcsh:Genetics Veterinary language business Arrhythmia Demography |
| Zdroj: | Canine Genetics and Epidemiology, Vol 6, Iss 1, Pp 1-5 (2019) Canine Genetics and Epidemiology |
| ISSN: | 2052-6687 |
| Popis: | Background Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North American Irish Wolfhounds using phenotype data from cardiac screenings performed between 2000 and 2019 in order to determine how much of this disease can be attributed to genetics compared to environmental causes. The second aim was to determine the disease mode of inheritance to help inform prevention and breeding practices. Results There were 327 Irish Wolfhounds diagnosed with AF and 136 Irish Wolfhounds over 8 years of age without AF. The estimated mean (95% confidence interval) heritability of AF in Irish Wolfhounds was 0.69 (0.50–0.86). The pedigree was consistent with a dominant mode of inheritance. Conclusion Results of this study indicate a strong genetic contribution to AF in Irish Wolfhounds and suggest that future research to identify causative genetic mutations is warranted. |
| Databáze: | OpenAIRE |
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