Differential Expression of Dysadherin in Papillary Thyroid Carcinoma and Microcarcinoma: Correlation with E-cadherin
| Autor: | Niki J. Agnantis, Chrissoula D. Scopa, Yukihiro Nakanishi, Konstantinos Charalabopoulos, Setsuo Hirohashi, Constantine E Vagianos, Anna Batistatou |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Endocrinology Diabetes and Metabolism Membrane Glycoproteins/*biosynthesis Gene Expression Carcinoma Papillary Follicular Biology Ion Channels Pathology and Forensic Medicine Correlation Thyroid carcinoma Endocrinology Cadherins/*metabolism Downregulation and upregulation medicine Humans Thyroid Neoplasms chemistry.chemical_classification Membrane Glycoproteins Neoplasm Proteins/*biosynthesis Cadherin Microfilament Proteins Thyroid Thyroid Neoplasms/*metabolism/*pathology General Medicine Adhesion Cadherins Immunohistochemistry Neoplasm Proteins medicine.anatomical_structure chemistry Carcinoma Papillary Follicular/*metabolism/*pathology DYSADHERIN Glycoprotein |
| Zdroj: | Endocrine Pathology. 19:197-202 |
| ISSN: | 1559-0097 1046-3976 |
| DOI: | 10.1007/s12022-008-9035-1 |
| Popis: | Dysadherin is a novel glycoprotein, with an anti-cell-cell adhesion function. The aim of the present study was to examine the expression of dysadherin in thyroid papillary microcarcinoma (PMC), to associate it with the expression of E-cadherin and to investigate whether there are differences with papillary carcinoma (PC). A statistically significant difference in dysadherin and E-cadherin expression between PC and PMC and a negative correlation between E-cadherin and dysadherin expression regardless of tumor size were noted. Based on these findings it is hypothesized that retained cell-cell adhesion, through maintenance of the E-cadherin adhesion system, in PMC prevents neoplastic cells from dissociating easily from each other and metastasizing. Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia. Endocr Pathol |
| Databáze: | OpenAIRE |
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