Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry
| Autor: | Christian Rolando, Maria A. van Agthoven, Peter B. O’Connor, Marc-André Delsuc, Yuko P. Y. Lam |
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| Přispěvatelé: | Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - USR 3290 (MSAP), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 (MSAP), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP], Centre de Biochimie Structurale [Montpellier] [CBS] |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
030103 biophysics Technical Primer Biophysics Analytical chemistry Mass spectrometry Tandem mass spectrometry Fourier transform ion cyclotron resonance Ion 03 medical and health sciences symbols.namesake Fragmentation (mass spectrometry) [CHIM.ANAL]Chemical Sciences/Analytical chemistry Tandem Mass Spectrometry Two dimensional [CHIM]Chemical Sciences Fourier Analysis Chemistry General Medicine Cyclotrons Fourier transform Fourier transform ion cyclotron resonance mass spectrometry 030104 developmental biology Mass spectrum symbols |
| Zdroj: | European Biophysics Journal European Biophysics Journal, Springer Verlag (Germany), 2019, 48 (3), pp.213-229. ⟨10.1007/s00249-019-01348-5⟩ European Biophysics Journal, 2019, 48 (3), pp.213-229. ⟨10.1007/s00249-019-01348-5⟩ |
| ISSN: | 1432-1017 0175-7571 |
| Popis: | International audience; Fourier transform ion cyclotron resonance mass analysers (FT-ICR MS) can offer the highest resolutions and mass accuracies in mass spectrometry. Mass spectra acquired in an FT-ICR MS can yield accurate elemental compositions of all compounds in a complex sample. Fragmentation caused by ion-neutral, ion-electron, or ion-photon interactions leads to more detailed structural information on compounds. The most often used method to correlate compounds and their fragment ions is to isolate the precursor ions from the sample before fragmentation. Two-dimensional mass spectrometry (2D MS) offers a method to correlate precursor and fragment ions without requiring precursor isolation. 2D MS therefore enables easy access to the fragmentation patterns of all compounds from complex samples. In this article, the principles of FT-ICR MS are reviewed and the 2D MS experiment is explained. Data processing for 2D MS is detailed, and the interpretation of 2D mass spectra is described. |
| Databáze: | OpenAIRE |
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