Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system

Autor: Steven L. Gonias, Michael A. Banki, Pardis Azmoon, Haylie K. Romero, Christina J. Sigurdson, Elisabetta Mantuano, Wendy M. Campana
Rok vydání: 2021
Předmět:
Zdroj: The Journal of biological chemistry. 298(3)
ISSN: 1083-351X
Popis: Exosomes and other extracellular vesicles (EVs) participate in cell-cell communication. Herein, we isolated EVs from human plasma and demonstrated that these EVs activate cell signaling and promote neurite outgrowth in PC-12 cells. Analysis of human plasma EVs purified by sequential ultracentrifugation using tandem mass spectrometry indicated the presence of multiple plasma proteins, including α
Databáze: OpenAIRE