Synergistic inhibition of human immunodeficiency virus isolates (including 3'-azido-3'-deoxythymidine-resistant isolates) by foscarnet in combination with 2',3'-dideoxyinosine or 2',3'-dideoxycytidine
| Autor: | Susan Cox, Sarah Palmer, J. Harmenberg |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Foscarnet
Microbial Sensitivity Tests Biology Antiviral Agents Peripheral blood mononuclear cell Monocytes 2'3' dideoxyinosine Virus Microbiology Zalcitabine Zidovudine 2'3' dideoxycytidine medicine Humans Pharmacology (medical) Cytotoxicity Cells Cultured Pharmacology Drug Resistance Microbial Drug Synergism Virology Didanosine Drug Combinations Infectious Diseases HIV-1 Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 40:1285-1288 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.40.5.1285 |
| Popis: | The combinations of foscarnet plus 2',3'-dideoxyinosine and foscarnet plus 2',3'-dideoxycytidine synergistically inhibit the replication of human immunodeficiency virus type 1 isolates, including two 3'-azido-3'-deoxythymidine-resistant isolates. The combination of 2',3'-dideoxyinosine plus 2',3'-dideoxycytidine showed additive inhibition of the majority of the human immunodeficiency virus isolates tested. All three combinations showed pronounced antagonistic cytotoxicity and thus were less toxic to the growth of peripheral blood mononuclear cells than the separate drugs. |
| Databáze: | OpenAIRE |
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