Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study
| Autor: | Irene Shayo, John Bartlett, Linda Minja, Michael E Irira, Blandina T. Mmbaga, Joshua Youze, James S. Ngocho, Venancia Komba, Francis Karia |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Cross-sectional study HIV Infections Malignancy Article 03 medical and health sciences 0302 clinical medicine Interquartile range Neoplasms medicine Prevalence Humans Child Retrospective Studies business.industry Medical record virus diseases Retrospective cohort study Hematology Odds ratio medicine.disease Kenya Clinical trial Cross-Sectional Studies Oncology 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health HIV-1 Female Sarcoma business 030215 immunology |
| Zdroj: | J Pediatr Hematol Oncol |
| ISSN: | 1536-3678 |
| Popis: | Objective We aimed to establish the prevalence of human immunodeficiency virus (HIV)-associated malignancies in children attending a care and treatment clinic at Kilimanjaro Christian Medical Centre. Materials and methods This was a retrospective cross-sectional hospital-based study of children who attended an HIV care and treatment clinic between 2006 and 2014. Children 2 months to 17 years of age were eligible for participation. The data on social demographic and clinical characteristics were extracted from the medical record. A multivariate logistic regression model was developed to determine predictors of HIV-associated malignancies. Results Medical records from 721 HIV-infected children were reviewed. The median age (interquartile range) at HIV diagnosis was 5.7 (2.0 to 9.4) years. Among them, 34 (4.7%) had HIV-associated malignancies. The most common (n=24, 70.3%) malignancy was the Kaposi sarcoma. Age at HIV diagnosis was significantly associated with HIV-associated malignancies (adjusted odds ratio, 1.2; 95% confidence interval, 1.0-1.3). Among 34 patients with HIV-associated malignancies, 11 (32.4%) died. Seven (20.6%) patients reported complete remission from their malignancies, and outcomes for 6 patients were unknown. Conclusions The prevalence of HIV-associated malignancies was high and was associated with late HIV diagnosis. The Kaposi sarcoma was the commonest malignancy. Early HIV diagnosis and treatment in children might reduce HIV-associated malignancies. |
| Databáze: | OpenAIRE |
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